{"id":10627,"date":"2024-02-12T13:12:58","date_gmt":"2024-02-12T11:12:58","guid":{"rendered":"https:\/\/alivitpharm.djole.dog\/?page_id=10627"},"modified":"2024-02-13T15:35:29","modified_gmt":"2024-02-13T13:35:29","slug":"folna-kiselina","status":"publish","type":"page","link":"https:\/\/alivitpharm.djole.dog\/sr\/folic-acid\/","title":{"rendered":"Folna kiselina"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"10627\" class=\"elementor elementor-10627\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a964ede elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a964ede\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cdf7650\" data-id=\"cdf7650\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b6d2cba elementor-widget elementor-widget-heading\" data-id=\"b6d2cba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Folna kiselina<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75711e1 elementor-widget elementor-widget-image\" data-id=\"75711e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/alivitpharm.djole.dog\/wp-content\/uploads\/2022\/10\/pill.png\" title=\"pill\" alt=\"Pill\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90a736a elementor-widget elementor-widget-text-editor\" data-id=\"90a736a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Pteroilglutaminska kiselina<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a142563 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a142563\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-66bbb0b\" data-id=\"66bbb0b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2abd23d elementor-widget elementor-widget-text-editor\" data-id=\"2abd23d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\"><strong>Folna kiselina<\/strong>, tako\u0111e poznata kao vitamin B9, je vitamin rastvorljiv u vodi.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">To je jedan od kompleksa vitamina B folne kiseline, koji odgovara pteroilglutaminskoj kiselini (PGA), ekstrahovan i pre\u010di\u0161c\u0301en iz listova spanac\u0301a od strane M. K. Mitchell (1941) i zove se folna kiselina.<\/span><\/span><\/p><p>Folna kiselina je neophodna supstanca za ljudsko telo u kori\u0161c\u0301enju \u0161ec\u0301era i aminokiselina i neophodna je za rast i reprodukciju c\u0301elija u telu.\n\t\t\t\nPoma\u017ee metabolizam proteina, a zajedno sa vitaminom B12 podsti\u010de proizvodnju i sazrevanje crvenih krvnih zrnaca, nezamenljiv je materijal za proizvodnju crvenih krvnih zrnaca, tako\u0111e deluje kao promotivni faktor za rast <em>Lactobacillus casei<\/em> i drugih mikroorganizama.<\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Folna kiselina je neophodna hranljiva materija za rast i razvoj fetusa.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Nedostatak folne kiseline kod trudnica mo\u017ee dovesti do niske poro\u0111ajne te\u017eine, rascepa usne i nepca i sr\u010danih mana pri ro\u0111enju.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Ako nedostatak folne kiseline u prva 3 meseca trudnoc\u0301e mo\u017ee izazvati defekte neuralne cevi fetusa, \u0161to rezultira deformitetom.<\/span><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-269af2d elementor-widget elementor-widget-image\" data-id=\"269af2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/alivitpharm.djole.dog\/wp-content\/uploads\/2022\/09\/leaves.png\" title=\"leaves\" alt=\"Leaves\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94b82d3 elementor-widget elementor-widget-text-editor\" data-id=\"94b82d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Folna kiselina igra va\u017enu ulogu u deobi c\u0301elija i rastu i sintezi nukleinskih kiselina, amino kiselina i proteina. Nedostatak folne kiseline u ljudskom telu mo\u017ee dovesti do stvaranja abnormalnih crvenih krvnih zrnaca, povec\u0301anja nezrelih c\u0301elija, anemije i smanjenja belih krvnih zrnaca.<\/span><\/span><\/p><p><span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Hiperhomocisteinemija ima duplo vecu sansu da bude uzrok smrti kod pacijenata sa dijabetesom nego kod zdravih osoba.<\/span><\/span> <span class=\"jCAhz ChMk0b\"><span class=\"ryNqvb\">Povecana vrednost homocisteina je jako cesta pojava kod osoba sa dijabetesom i folna kiselina se smatra jednim od glavnih faktora kontrole koncentracije  homocisteina u plazmi.<\/span><\/span><\/p><p>Dodatak folne kiseline (FAS) mo\u017ee zna\u010dajno smanjiti nivoe homocisteina i stoga  smanjuje  kardiovaskularni  rizik kod pacijenata sa dijabetesom tipa 2.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf304af elementor-widget elementor-widget-heading\" data-id=\"cf304af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Reference<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7379fa5 elementor-widget elementor-widget-text-editor\" data-id=\"7379fa5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Plasma homocysteine and all-cause mortality in diabetes. <em>Lancet.<\/em> 1999<\/li><li>Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus. <em>Diabetes Metab Res Rev. 2010<\/em><\/li><li><em>Tian T, Yang KQ, Cui JG, Zhou LL, Zhou XL (October 2017).<\/em> &#8220;Folic Acid Supplementation for Stroke Prevention in Patients With Cardiovascular Disease&#8221;. <em>Am. J. Med. Sci. 354 (4): 379\u2013387.<\/em><\/li><li><a class=\"reference-link\" href=\"https:\/\/ods.od.nih.gov\/factsheets\/folate-HealthProfessional\/\" target=\"_blank\" rel=\"noopener\">Folate &#8211; Fact Sheet for Health Professionals <em>Office of Dietary Supplements, US National Institutes of Health. 29. March 2021. Retrieved 29. April 2022.<\/em><\/a><\/li><li><em>Welch AD (1983).<\/em> &#8220;Folic acid: discovery and the exciting first decade&#8221;. <em>Perspect.<\/em> <em>Biol. Med. 27<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Folic Acid Pteroylglutamic Acid Folic acid, also known as vitamin B9, is a water-soluble vitamin. It is one of the vitamin B complexes of folic acid, corresponding to pteroylglutamic acid (PGA), extracted and purified from spinach leaves by M. K. Mitchell (1941) and called folic acid. Folic acid is a necessary substance for the human [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-10627","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/pages\/10627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/comments?post=10627"}],"version-history":[{"count":0,"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/pages\/10627\/revisions"}],"wp:attachment":[{"href":"https:\/\/alivitpharm.djole.dog\/sr\/wp-json\/wp\/v2\/media?parent=10627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}